Abstract
Objective: The objective of this study is to determine the outcome of bone allograft in orthopaedics patients.
Material and Methods: This descriptive case series was conducted in the Department of Orthopaedic and Trauma, Northwest
General Hospital Peshawar from August 10, 2018 – February 10, 2019. Thirty-six patients were selected using non-probability consecutive sampling technique. Patients between ages 18-60 years, of either gender with confirmed diagnosis of
structural bone defect requiring bone grafting were included. However, patients with metabolic bone disorders associated
with poor bone healing, active infection at grafting site and terminally ill patients were excluded.
Results: Of the thirty-six patients included, there were 27 (75%) males and 9 (25%) females with a mean age of 38.4 ± 15.4
years. The most common diagnosis among the study patients was traumatic femur shaft defect, which comprised of 10
(27.8%) patients followed by traumatic tibial shaft defect with 6 (16.7%) patients and traumatic femoral subtrochanteric defects were in 5 (13.9%) patients. Other indications for allograft placement in our study population was femoral shaft defect
after tumor resection (n = 4, 11.1%), neck of femur non-union (n = 3, 8.3%), tibial plateau fracture (n = 2, 5.6%), femoral subtrochanteric defect after tumor resection (n = 1, 2.8%). The most common surgical procedures included Dynamic Condylar
Screw in 9 (25%) patients, external fixation in 8 (22.2%), plating in 7 (19.4%), 5 (13.9%) Interlocking Nail, 3 cases (8.3%) each
of dynamic Hip Screw and scraping and one (2.8%) case of posterior spinal fixation. Postoperatively, infection was noted
in 4 (11.1%) of cases, instability in 5 (13.9%) cases, non-union in 4 (11.1%) and tumor recurrence in 3 (8.3%) of patients.
Conclusion: Increase in treatment modalities (use of chemotherapy in combination with radiotherapy) leads to significant
increase in complications associated with the use of structural allograft including infection and non-union. A great deal of effort is required to prevent these complications that adversely affect the survival of grafted tissue including infection, fracture,
recurrence of disease and non-union.
Waqas Raza, Pushtoon Sherzad, Raja Irfan Qadir. (2020) OUTCOME OF BONE ALLOGRAFT IN ORTHOPAEDIC PATIENTS, Journal of Medical Sciences, Volume 28, Issue 3.
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