Abstract
Gliomas are one of the most annihilating types of brain
tumours having a high rate of annual incidence
worldwide. Notch signaling is an evolutionary conserved
pathway that regulates differentiation and development.
Aberrations in Notch signalling pathways lead to severe
pathological state such as the Gliomas. MicroRNAs
(miRNAs) are the tiny molecules less than 200 bps in
length and regulate a myriad of cellular processes.
Categorically, miRNAs are divided in to oncogenic and
tumours suppressor miRNAs. Accumulating data have
identified miRNAs, which positively or negatively regulate
Notch signaling in Gliomas. Here, we have assessed status
of our understanding of the interplay between miRNAbase regulation of Notch signaling in gliomas, interaction
between Notch signaling and other signaling cascades
and have also discussed use of natural compounds that
will help us get closer to personalized medicine for
gliomas.
Zeeshan Javed, Qamar Raza, Faiez Ahmad Shah, Haleema Sadia, Ayesha Alam, Faiza Anum, Mushtaq Ahmad Saleem, Shahid Raza. (2021) Notch Signaling & MicroRNAs — two tumblers of neurogenesis and Gliomas , Journal of the Pakistan Medical Association, Volume 71, Issue 1.
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