Abstract
Objective: To determine the effectiveness of cell block technique by comparing cytomorphological features on
cell blocks and conventional fine needle aspiration smears and to assess the utility of combined approach for
cytodiagnosis.
Study Design: Cross sectional study.
Place and Duration of Study: Pathology Department of Pakistan Railway Hospital Rawalpindi and Pakistan
Institute of Medical Sciences from April 2017 to April 2018.
Materials and Methods: Sixty cases were included in the study through non- probability convenient sampling.
All patients having palpable solitary or dominant thyroid nodules were included in the study. In addition to the
routine cytological smears, cell blocks were prepared from the residual aspirates and cytomorphological
criteria like cellularity, obscuring background material, morphological and architectural preservation were
compared. Data was analyzed using SPSS software version 21. Wilcoxon signed rank test was used for significant
difference. P value ≤ 0.05 was considered significant.
Results: Male to Female ratio was 1:6.5 (13%: 87%). Age ranged from 22 to 81 years with mean age of 44.9 and
standard deviation of ±14.5 years.
According to the Mair et al scoring system, the mean values for the cellularity and morphological preservation
parameters of the cell block technique were 0.86 and 1.13, while that of the cytological smears were 0.95 and
0.86 simultaneously. And the mean values for the obscuring background material and architectural
preservation of the cell block technique were 1.13 and 0.82 and that of the cytological smears were 0.86 and
0.54 simultaneously.
Conclusion: Cell block technique was found effective in decreasing obscuring background material and in
preserving architectural preservation. Hence, this technique facilitated in the diagnosis when reviewed along
with the cytological smears.
Siyab Ahmad, Umer Muhammad Azam Khan, Ammar ul Hassan, Madiha Sajjad Minhas, Samina Iltaf. (2019) Comparison of Direct Smear and Cell Block Preparation for the Evaluation of Thyroid Epithelial Lesions on Fine Needle Aspiration, Journal of Islamic International Medical College, Volume-14, Issue-2.
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