Abstract
Objective: To evaluate the efficacy and safety of collagen cross linking in stabilizing the visual acuity and
keratometric readings one year after the procedure.
Study Design:A Case Series.
Place and Duration of Study: All the procedures were performed at Amanat Eye Hospital Rawalpindi from
January to June 2011.
Materials and Methods: Sixteen cases suffering from progressive keratoconus which underwent collagen
cross-linking were analyzed retrospectively. After epitheliectomy and instillation of topical Riboflavin, UV light
exposure was given for 30 min. A bandage contact lens was applied postoperatively for 5 days. The patients
were followed up after 5 days, one month, 3 months, 6 months and then one year. During all the postoperative
visits, visual acuity, slit lamp examination and keratometry were performed.
Results: Sixteen cases completed one year's follow-up. Un-corrected visual acuity improved in 12 out of 16
eyes, remained stable in 4 out of 16 and deteriorated in none. Best-corrected visual acuity improved in 9 out of
16 eyes, remained stable in 6 out of 16 and deteriorated in one out of 16.
Mean pre-operative Keratometry was 50.23 D which reduced to 49.77 D after one year. Progression of original
disease (increase in K-value by > 0.50 D) was seen in only 2/16 eyes after one year of follow-up. Keratometric
improvement (decrease in K-value by > 0.50 D) was seen in 6/16 eyes while 8/16 eyes (50%) showed
keratometric stability (i.e. K-value within 0.50 D of the preoperative value).
Conclusion: Collagen cross-linking is effective and safe in providing visual and keratometric stability for
keratoconus.
Aneeq Ullah Baig Mirza, Aamir Asrar, Bisma Ikram. (2017) Efficacy and Safety of Corneal Collagen Cross-linking in Keratoconus; A One Year Follow-up, Journal of Islamic International Medical College, Volume-12, Issue-1.
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