Abstract
OBJECTIVE: To assess the effectiveness of honey dressing in Fournier’s Gangrene against
conventional Edinburgh University solution of lime (EUSOL) dressing.
METHODOLOGY: This was a prospective experimental study conducted in Liaquat National Medical
College and Hospital Karachi for duration of 5 and half years. Total 44 patients having gangrene and no
co morbid conditions were included in this study. Patients who had co-morbid conditions like deranged
coagulation profile and CVA, who were not willing to participate or loss to follow up were excluded from
the study. After getting baseline blood workup (i.e. CBC, S. Creatinine, S. Electrolytes, Urine D/R, C/S
and Diabetic workup) done and taking consent, the patients were immediately shifted to operation
theatre, the incision and drainage was performed, and the necrotic tissues were debrided. Pus cultures
were sent, and patients were started on routine intravenous antibiotics (3rd generation Cephalosporin
and metronidazole). A Dressing of wound was done randomly by honey in Group A and by Eusol in
Group B. Patients were discharged after wound was completely healed. The data were obtained and
analyzed by using SPSS version 20. Mann-Whitney U-test and chi-square test was applied to find out the
significance.
RESUTS: The patients in Group A got slough cleared in4.82±0.96 days, on average requiring 3.22±0.75
number of debridement’s, complete wound healing and duration of hospital stay being 9.54±0.74 days.
The patients in Group B got slough cleared in 8±0.87 days, requiring 5.32±0.72 number of debridement’s,
complete wound healing and duration of hospital stay 13.68±1.09 days.There was a significant difference
in slough clearance, number of debridement’s required, time taken for complete wound healing and
hospital stay between Group A and Group B (P-value <0.001).
CONCLUSION: This study predicted that honey is very valuable in the management of Fournier’s
gangrene as it ensured early clearance of slough, required lesser number of debridement’s, had early
wound healing and had relatively shorter duration of stay in hospital than those treated with
conventional EUSOL as dressing material
Syed Farhan Ahmed, Imran Memon, Zakir Hussain Rajpar, Muhammad Asim, Adnan Anwar, Wajeeha Elahi. (2019) Management of Fournier’s Gangrene; A Randomized Controlled Trial at High Volume Center Comparing the Efficacy of Honey and Eusol Dressing in Wound Healing, Journal of Liaquat University of Medical and Health Sciences, Volume-18, Issue-1.
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