Abstract
OBJECTIVES: To observe and compare gross and histological changes of the placenta of nondiabetic and diabetic mothers. And observe possible changes in the fetal weight of diabetic and
non diabetic mothers.
STUDY DESIGN: Case control study.
PLACE AND DURATION: This study was conducted from June 2009 to July 2010 at the department of Anatomy of Liaquat University of Medical & Health Sciences Jamshoro. The placentae
were collected from department of Gynecology & Obstetrics of Liaquat University Hospital.
MATERIAL AND METHODS: Eighty freshly delivered placentae were collected forty placentae
from diabetic’s mothers & forty placentae from parturient belonged to uncomplicated pregnancy (control group). Ages of all parturient were between 17 to 32 years. Fetal outcome and
data was recorded. Placentae were measured on a weighing machine graduated in grams and
diameter was measured with the help of a measuring tape in centimeters. Approximately five
mm piece of from diabetic placenta was taken and processed for histological examination. Fetal
weight was also recorded.
RESULTS: Morphological examination of placentae showed larger, heavier and more cotyledenous placentae group as compared to controls. Similarly microscopic examination revealed
dilated blood vessels, necrotic and degenerative foci in placentae of diabetics as compared to
controls.
CONCLUSION: Diabetes Mellitus produces profound gross as well as histological changes in
placentae which might result in large for date babies because of fetal compromises. A good
glycemic control might be a better option for reducing diabetes induced abnormalities.
Lal Baksh Khaskhelli, Samreen Memon, Pushpa Goswami , Shamshad Bano. (2013) Change in Normal Morphology of Placenta and Its Possible Effects on Fetal Outcome in Diabetic Mothers as Compared to Non-Diabetic Mothers , Journal of Liaquat University of Medical and Health Sciences, Volume-12, Issue-1.
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