Abstract
Background: Insulin resistance, a major pathogenic factor in Gestational Diabetes Mellitus (GDM), has an
inverse correlation with adiponectin; therefore, the role of adiponectin in the pathogenesis of GDM has
been suggested. The study aimed to determine mean adiponectin levels and the frequency of
hypoadiponectinemia in patients with GDM.
Methods: The study was carried out at Dr. Ziauddin University Hospital, Karachi from June 2016 to December
2017. A total of 99 women of age group 15-45 years diagnosed with GDM on Oral Glucose Tolerance Test
(OGTT) at 24-28 weeks of gestations were included in the study. Patient’s data was recorded on proposed
proforma, regarding age, gestational age, parity, ethnicity, Body Mass Index (BMI). Serum samples for
quantitative estimation of Adiponectin were collected while performing OGTT and were analyzed on
Immunoassay in conjunction with control materials. Mean±Std. was calculated for quantitative variables.
Percentages and frequencies were calculated for categorical variables. For significant differences
between categories, an independent t-test and Chi-square test were used.
Results: High frequency of hypoadiponectinemia was observed in GDM women with mean adiponectin
levels of 6.90±2.86 µg/ml (95%CI: 6.33 to 7.47). Out of 99 GDM women, 91(91.92%) had hypoadiponectinemia
while 8(8.08%) had normal Adiponectin levels. A significant (p=0.05) association was found between BMI
and hypoadiponectinemia.
Conclusion: In the majority of GDM females, hypoadiponectinemia was observed. The high frequency of
hypoadiponectinemia suggests further large-scale studies, are warranted to ascertain the diagnostic
accuracy of adiponectin as a potential biomarker for GDM.
Saba Raza, Usman Ali, Adnan Mustafa Zubairi, Erum Salim. (2021) Mean Adiponectin Levels and Frequency of Hypoadiponectinemia in Gestational Diabetes Mellitus, The Pakistan Journal of Medicine and Dentistry, Volume 10, Issue-1.
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