Abstract
Coronary artery disease (CAD) is a leading cause of death worldwide. The
death rate is decreasing in developed countries due to awareness, but the
disease burden is increasing in developing countries. Pakistan is a country
with high prevalence of CAD. The serum lipids have long been implicated
in the development of CAD by the deposition of mainly LDL on endothelial
lining resulting in atherosclerosis. Progression to CAD involves
environmental as well as genetic factors. The genetic component is due to
the contribution from various low to modest effect size variants in many
genes. Common variants have been used to construct a genetic risk score
(GRS) to calculate the risk of future CAD. In conclusion, lifestyle
interventions in concert with the knowledge of genetic predisposition based
on family history and use of population data may one day lead to the
development of personalized medicine for the treatment and prevention of
CAD
Saleem Ullah Shahid, Shabana. (2021) Coronary Artery Disease (Cad): Interplay Of Nutrition, Serum Parameters And Genetics, Pakistan Heart Journal, Volume-54, Issue-1.
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