Abstract
Background: Extended Spectrum β-lactamases (ESBLs) are emerging as common nosocomial pathogens and important cause of mortality and morbidity, if not treated properly.The need of the hour is to find effective treatment options for dealing with ESBL producing organisms. This study was aimed to evaluate invitro susceptibility pattern of extended spectrum β-lactamase producers against tetracyclines.Methods: This descriptive cross-sectional study was carried out in the department of Microbiology, Army Medical College, Rawalpindi, National University of Sciences and Technology over a period of 6 months.Seventy eight non-duplicate isolates were included in the study. ESBL detection was done using Jarlier et al method.Invitro susceptibility of tetracyclines like tetracycline, doxycycline, minocycline and tigecycline was then tested using Modified KirbyBauer disc diffusion method. The zones of inhibition were measured after completion of incubation period and interpreted as per CLSI and FDA guidelines. Results: Approximately56.4%of the isolates were Escherichia coli, 28.2% were Klebsiella pneumoniae, 10.26% were Enterobacter species, and 2.6% were each Klebsiellaoxytoca and Acinetobacter species. ESBLs were found to be most sensitive to tigecycline, intermediate in susceptibility to minocycline while least sensitive to doxycycline and tetracycline.Conclusion: Among tetracyclines, tigecycline has best invitrosusceptibility against ESBL producing Gram negative rods
Maria Mushtaq Gill, , Javaid Usman, Afreenish Hassan, Fatima Kaleem, Nasira Shaheen. (2015) INVITRO SUSCEPTIBILITY PATTERN OF EXTENDED SPECTRUM Β-LACTAMASE PRODUCING GRAM NEGATIVE BACILLI AGAINST TETRACYCLINES, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 27, Issue 4.
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