Abstract
Super drug resistance (PDR / EDR) in microbial strains has been a
continuous phenomenon in nosocomial and miscellaneous infections. The
load of these bugs has inflated over worldwide. Microbes evolve such
phenomena involving mutational processes, hyper performance of
pumping out systems, synthesis of secretory saccharides,
bioaccumulation and directed flagella based shifting resulting out of hypodoses of drug stimulation. Further, the prevalence of Enterobacteriaceae
member strains has been witnessed producing Extended Spectrum βLactamases (ESBLs) and Carbapenemases. Drug resistance in viral
entities has also posed challenge for public health programs. About 20%
people die of viral hepatitis in one of Pakistan provinces. A counter
malarial acrine drug is being tried against proteinaceous infectious
particles (causing many transmissible neuro-diseases). These
epigenetical agents have been a source of concern for our planet
regarding food safety issues (e.g. infected meat). No doubt, man has
made significant achievements in effective and neo-antimicrobials
research, one wonders why not a single infectious agent has been
completely knocked out. Our group has been focusing on ascertaining the
basis of antibiotic deferring processes acquired by (indigenous) clinical
strains. Accordingly, sub-lethal doses of the drug result in development of
hyper-resistances. The bacteria have evolved the molecular genetical
basis (and other parameters) for acquiring the resistance. For the
containment and eradication of globally evolving MDR bacteria, it is
crucial to understand and implement certain strategies/agents such as,
probiotics, CRISPRs, bacteriophages, nanotechnology and
phytochemicals.
SHEIKH AJAZ RASOOL, MUHAMMAD SALMAN RASOOL, MUNAZZA AJAZ. (2019) Evolution of super-drug resistant microbial strains: mechanisms and strategies for containment, Biologia – Journal of Biological Society of Pakistan, Volume 65 (II), Issue 2.
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