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Objective: To compare the effectiveness of alpha blocker and phytotherapy
in relieving the lower urinary tract symptoms (LUTS) in patients with Benign
Prostatic Hyperplasia (BPH).
Methodology: This randomized controlled trial was conducted in Department of Urology, Institute of Kidney Diseases, Peshawar from June 2017 to
December 2018. A total of 308 patients, divided randomly in two groups,
with 154 patients in each group, were enrolled using consecutive sampling.
Group A received tamsulosin (alpha blocker) while patients in group B were
put on Saw Palmetto as Phytotherapy. International Prostate Symptom Score
(IPSS) and Uro-flowmetry were recorded before the therapy after 1st, 2nd,
3rd and 6th months respectively. A pre-designed proforma was used to enter
the data, which was analyzed on SPSS version 20.0. Descriptive and inferential
statistics were calculated where needed.
Results: Mean age in group A was 65.1 ± 7.09 years, while group B showed
64.7 ± 8.01 years (p=0.442). The mean of IPSS before initiation of treatment
in group A was 15.3 ± 3.02 and in group B it was 16.2 ± 3.04 (p=0.07), while
post treatment IPSS at 6 months, in group A mean was recorded as 8.5 ± 7.4
and in group B it was 12.07 ± 2.75 (p=0.01). In Uroflowmetry, group A showed
mean pre-treatment maximum flow as 8.4 ± 1.3 and in group B it was 8.2 ±
1.1 (p=0.064), while post-treatment maximum flow at 6 months for group A
showed mean of 11.8 ± 1.5 and group B had 8.2 ± 1.1 (p=0.001).
Conclusion: Alpha blockers are more effective than Phytotherapy in management of symptomatic BPH.
Liaqat Ali, Faiza Hayat, Samieullah Opal, Saifullah, Kifayat Tariq, Qudratullah. (2020) COMPARISON OF PHYTOTHERAPY WITH ALPHA ADRENOCEPTERS BLOCKERS IN THE TREATMENT OF SYMPTOMATIC BENIGN PROSTATIC HYPERPLASIA, Journal of Postgraduate Medical Institute, Volume 4, Issue 2.
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