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. In this paper, we modify Cronin’s model by defining the toxins generated by the organ mass compartment as the sum of the toxins
used up by the extracellular compartment and the muscles mass adipose
tissues compartment. The improved model clearly describes that the concentration of toxins for small patients remains low throughout the dialytic
interval. The interdialytic phase starts with the inverted replica of the dialytic interval; a natural physiological phenomenon. However, the concentration of toxins remains high throughout the interdialytic interval which
keeps the smaller patients comparatively at more mortality risks than the
larger patients during the maintenance hemodialysis. This phenomenon
is further verified by the time average concentration of the toxin in the
extracellular compartment.
Mohammad Munir, Asghar Ali, Rashida Hussain. (2018) An Improved Mathematical Model of Solute Kinetic During Hemodialysis, Punjab University Journal of Mathematics, Volume 50, Issue 1.
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