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Scores of intricate problems are churned out in mammalian cell owing to the influence of lipophilic aromatic hydrocarbons. Diffusion and reaction of these noxious compounds obliterate
the cellular structure. Earlier, a mathematical model was developed
which gives rise to a system of PDEs. This system was treated
numerically. Homogenization technique was used for the numerical
treatment of cytoplasm which reduced the complexity of the model.
The disparity in the formation of tetrols guides us towards a new
model comprising nuclear envelope, enzymatic reactions and modifying the nuclear size. The results of the model are compared with
previous model and experimental results of V79 cells, which show
a significant improvement in the model.
Misbah Gul, Qasim Ali Chaudhry, Naima Abid, Saira Zahid. (2015) Simulation of Drug Diffusion in Mammalian Cell, Punjab University Journal of Mathematics, Volume 47, Issue 2.
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