تلخیص
Objective: To analyze the resistance patterns of antibiotics against infectious agents causing blood, urine and pus infections.
Study Design: Prospective experimental study.
Place and Duration: Pharmaceutical Microbiology Lab, Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University,
Karachi from 8th January to 21st June 2018.
Methodology: As 126 Clinical isolates of E.coli and Klebsiella spp. were collected from various pathological laboratories of Karachi.
Antimicrobial susceptibility testing was performed by Kirby-Bauer method for disks of four antibiotics; Imipenem, Cefotaxime,
Nalidixic acid and Gentamicin.
Results: Among 126 clinical isolates, (66%) are Escherichia coli, (34%) are Klebsiella species. (63%) isolates have been obtained from
the urine culture, (33%) from blood and (4%) from pus causing urinary tract infection, bacteremia and soft tissue infection
respectively. Imipenem is found to have significantly (p=0.0001) highest susceptibility against E.coli (87%) and Klebsiella
specie.(91%). However, E.coli (40%) and Klebsiella specie. (93%) are highly resistant from Cefotaxime, while almost 50% organism
are resistant from Gentamicin (53%) and Nalidixic acid (33%).
Conclusion: Imipenem has been found to be the most effective of all tested antibiotics while Cefotaxime has developed resistance
from these microorganisms.
Fatima Iqbal Khan, Bilqees Fatima, Sheikh Abdul Khaliq. (2019) Anti-microbial suseptability of Escherichia coli and Klebsiella spp: A review of 126 clinical isolates., Isra Medical Journal, Volume 11, Issue 4 (Part-B).
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