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Objective: To study the relationship of serum Mullerian inhibiting hormone with gonadotrophins in females with infertility.
Study Design: A Cross Sectional study.
Place and Duration: The study was conducted in the Infertility Clinic of a tertiary care hospital in Karachi from 1st February 2012 to 20th January 2013.
Methods: A total of fifty women with no history of any previous pregnancy i.e. primary infertility, between 18-33 years of age, patent fallopian tubes and normal semen analysis of their husbands were selected from the infertility clinic. Blood samples for basal follicle stimulating hormone, leutinizing hormone and Mullerian inhibiting hormone levels were assessed.
Results: The mean serum level for follicle stimulating hormone was 8.82±1.402. Mean leutinizing hormone and Mullerian inhibiting hormone levels were found to be 7.51±3.23 mIU/ml and 1.32± 0.74ng/ml respectively. Statistical analysis revealed a strong negative and significant relationship between Mullerian inhibiting hormone and follicle stimulating hormone, though leutinizing hormone had inverse but insignificant correlation with Mullerian inhibiting hormone.
Conclusion: Mullerian inhibiting hormone was negatively associated with the gonadotrophins in infertile women and significant inverse correlation was found between MIH with FSH compared to the insignificant negative association with the leutinizing hormone. Therefore, MIH can be considered as a surrogative marker in the assessment of ovarian reserve.
Key Words: Mullerian inhibiting hormone, luteinizing hormone, follicle stimulating hormone, infertility, gonadotrophins, reserve.
Naila Parveen, Dureshahwar Rehman, Naseer Baloch, Komal Masroor. (2018) Association of serum Mullerian inhibiting hormone with the gonadotrophins in infertile women, Isra Medical Journal, Volume 10, 01.
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