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Background: Insulin resistance in pregnancy and gestational diabetes is an important cause of mortality and morbidity. We aimed to compare serum insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and serum adiponectin between normal non-pregnant and pregnant women to see the correlation between adiponectin and insulin resistance in normal pregnant women. Methods: This case control study was conducted at Army Medical College and Centre for Research in Experimental and Analytical Medicine (CREAM) and Military Hospital, Rawalpindi. Sixty subjects were recruited. Group I had 30 normal healthy women. Group II consisted of 30 age and BMI matched 2 nd trimester pregnant women with normal glucose tolerance. Women with diabetes, history of miscarriage or inflammatory disease were excluded. ELISA was used to measure serum insulin and adiponectin levels. Glucose levels were measured with glucometer. HOMA-IR was used to assess the insulin resistance (IR). Mean values were calculated. Independent samples t-test was used to compare the means of the parameters. Pearson correlation test was applied to evaluate the correlation between variables in the groups, and p<0.05 was considered as significant. Results: Serum Insulin and HOMA-IR levels were significantly different between group I and group II (p=0.000), however, serum adiponectin levels in both groups were not significantly different. Small, non-significant negative correlation was observed between serum adiponectin and HOMA-IR in group II (p>0.05). Conclusion: Non-significant negative correlation between serum adiponectin and HOMA-IR reveals that there might be factors other than serum adiponectin leading to IR in pregnant women

Javaria Sharafat, Maria Gill, Sara Naeem, Tallat Naureen, Sidra Arshad. (2020) DECIPHERING ADIPONECTIN-INSULIN RESISTANCE NEXUS IN NORMAL PREGNANT VERSUS NON-PREGNANT WOMEN, Pakistan Journal of Physiology, Volume 16, Issue 2.
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