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To determine the response rate to sofosbuvir and ribavirin in chronic Hepatitis C Virus (HCV) patients who did not
respond or relapsed with interferon therapy. A case series study was performed at Jinnah Postgraduate Medical
Centre (JPMC), Karachi from January 2017- January 2019. HCV RNA positive were initiated in eligible patients with
sofosbuvir 400mg once daily and ribavirin 400mg orally according to body weight for six months. Rapid viral
response (RVR) [normal/undetectable ALT and AST level or very low HCV RNA at 4-6 weeks]. HCVRNA, CP, ALT
were checked after 3 months of stopping treatment to confirm sustained virologic response (SVR). Of 100 cases,
16 (16%) were non-responders while relapse was observed in 84 (84%) patients. Among the 13 cirrhosis patients, 11
(84.6%) achieved SVR. Females had a significantly higher response rate as compared to males (p value 0.034). The
sustained virological response rate in interferon treated chronic hepatitis C patients retreated with sofosbuvir
and ribavirin was found satisfactory.
Shaimuna Fareeha Sajjad, Waquaruddin Ahmed, Syed Ejaz Alam. (2020) Sofosbuvir and Ribavirin in Chronic Hepatitis C Virus Patients with No Response or Relapse with Interferon Therapy, Journal of the Dow University of Health Sciences, Volume 14, Issue 3.
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