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Objective: To assess the nephroprotective role of Ascorbic Acid against Aspartame induced nephrotoxicity in
Albino Wistar rats.
Study Design:Quasi-experimental study.
Place and Duration of Study: Postgraduate research laboratory at ISRA University, Hyderabad from August
2018 until November 2018.
Materials and Methods: Thirty albino Wistar rats were divided into three groups: Group I (Control group),
Group II (Aspartame only), and Group III (aspartame and ascorbic acid combination). Pre and post-experiment
body weight, the biochemical analysis was done through ANOVA. While Fisher's exact test was used for
histological analysis in SPSS version 22.
Results: Statistically significant difference in mean post-experimental body weight was observed in all three
groups (P-value<0.05). Marked reduction in mean body weight was observed in group II (171.4±17.5) as
compared to group III (191.80±15.1). A statistically significant difference in mean serum levels of serum
biomarkers was also observed in all three groups (P-value<0.05). Marked elevation in serum levels of urea,
creatinine, C-reactive protein while the decline in serum levels of glutathione peroxidase was seen in group II as
compared to group III. Histological alterations (mean diameter of proximal and distal renal tubules) were also
more pronounced in group II (110.3±7.4 and 185.98±5.9) respectively as compared with group III (89.59±6.1
and 95±6.8).
Conclusion: Aspartame consumption causes significant nephrotoxicity and disturbs normal renal functions.
Ascorbic acid used as a potent antioxidant can limit and/or decrease the toxic effects caused by aspartame
Sana Kashif, Kumayl Abbas Meghji, Tariq Feroz Memon, Shazia Parveen Channar, Jahanzeb Khan, Muhammad Shahab Hanif. (2020) Effects of Ascorbic Acid on Aspartame Induced Nephrotoxicity: An Experimental Rat Model, Journal of Islamic International Medical College, Volume-15, Issue-2.
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