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Objective: To observe the effects of Aescin and Atorvastatin on the lipid profile of Albino Wistar rats.
Study Design: Quasi-experimental study.
th Place and Duration of Study: Postgraduate research laboratory at ISRA University, Hyderabad from 6 June
th 2018 to 7 October 2018.
Materials and Methods: Fifty albino Wistar rats were divided into five groups: Group A (Control), Group B
(High-fat diet), Group C (Aescin + high-fat diet), Group D (Atorvastatin + high-fat diet), Group E (Aescin +
Atorvastatin + high-fat diet). Pre and post-experimental body weight and biochemical analysis was done
through ANOVA on SPSS version 22. The significance level was p ≤ 0. 05.
Results: Marked reduction in serum Total Cholesterol (71.36 ±10.1), Triglycerides (83 ±25.66), and Low-density
lipoprotein-cholesterol (32 ± 3.76) while elevation in levels of High-density lipoprotein-cholesterol (45 ± 11.85)
was observed in Group E as compared to Group B. Statistically significant difference in mean post-experimental
body weight body was also observed between all study groups (p ≤ 0.05).
Conclusion: Combination therapy of Aescin and Atorvastatin has significant protective effects on lipid profile
when compared with individual therapy of either drug.
Shazia Parveen Channar, Ali Abbas Thalho, Sana Kashif, Mozna Talpur, Asim Shafique Channar, Kumayl Abbas Meghji. (2020) Comparative Study of Aescin and Atorvastatin on Lipid Profile of Albino Wistar Rats, Journal of Islamic International Medical College, Volume-15, Issue-2.
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