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Objective: To compare the effect of topical 0.1% Nepafenac and 1% prednisolone in control of inflammation
and maintenance of Intraocular Pressure (IOP) after cataract surgery.
Study Design:Randomized control trial.
th th Place and Duration of Study: Department of Ophthalmology, from 4 June 2018 to 30 June 2019.
Materials and Methods: Total sample size of study population was 400, including all patients getting
phacoemulsification cataract surgery. Study population was equally divided in two groups. Group 1 was
Nepafenac group, and Group 2 was Prednisolone group. Both groups underwent cataract extraction, and were
started on topical 0.1% Nepafenac or 1% Prednisolone along with topical antibiotics after surgery. Postoperative IOP and activity and flare was checked in all patients on day 1, 7 and 28 after surgery and compared
between both groups. Results: The study population had a mean age of 60.97±4.91 years. The proportion of male and female patients
in study population was 51% and 49% respectively. Difference in mean post-operative IOP and mean change
from pre-operative value between both groups was statistically significant (p=0.003 and 0.004 respectively).
There was statistically significant difference between both groups in terms of anterior chamber cells and flare
respectively at 1st week post-operatively (p=0.002, and 0.003). However, there was no statistically significant
difference between both groups in terms of anterior chamber cells and flare respectively after 28 days postoperatively (p=0.12, and 0.71).Conclusion: Nepafenac is superior to prednisolone in controlling IOP after cataract surgery, with adequate and
comparable control of post-surgical inflammation.
Asim Mehboob, Muhammad Usman Arshad ,, Faran Bin Afzal, Sohail Zia, Aneeq Ullah Baig Mirza, Masud Ul Hassan. (2020) To Compare the Effect of Nepafenac versus Prednisolone on Post-Operative Inflammation and Intraocular Pressure after Cataract Surgery, Journal of Islamic International Medical College, Volume-15, Issue-1.
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