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Objective: The objective of this study was to determine the correlation of bacterial density with severity of the
degree of neutrophilic infiltrate, atrophy and intestinal metaplasia after analyzing the density of H. Pylori semi
quantitatively in chronic gastritis patients.
Study Design: The study was a cross sectional correlational study.
nd Place and Duration of Study: The study was conducted in Army Medical College Rawalpindi from 2 December
st 2011 to 1 December 2012.
Materials and Methods: A total of one hundred gastric antral biopsies of H. Pylori associated chronic gastritis
including all ages and both genders were included in the study. Most of the specimens that were received from
the department of Gastroenterology Military Hospital Rawalpindi were fixed in 10% formaline. The tissue was
processed in histopathology department. Giemsa stain was used for demonstration of H. Pylori. The density of
H. Pylori, activity, atrophy and intestinal metaplasia were graded using a detailed histopathological
classification. SPSS 17 was used to analyze the findings. Relationship between density of H. Pylori and other
variables was calculated through Spearman's rank correlation test. The findings were considered to be
statistically significant if p value was found to be less than 0.05 (p<0.05).
Results: An overall significant weak positive correlation was observed between grades of H. Pylori density and
degree of neutrophilic activity (r 0.416). There was significant but weak relationship between grades of H. s=
Pylori density and grades of atrophy (r 0.306). Intestinal metaplasia also revealed very weak association with s=
grades of H. Pylori density (r 0.287). s=
Conclusion: In conclusion this study shows the semi quantitative determination of histological parameters and
corroborates that, the greater the load of H. Pylori infection, the more is the degree of neutrophilic activity,
atrophy and intestinal metaplasia.
Henna Khalid, Alia Zubair, Nazma Kiran, Aiza Sadia. (2018) Histopathological Evaluation of H. Pylori Density and its Correlation with Activity, Atrophy and Intestinal Metaplasia, Journal of Islamic International Medical College, Volume-13, Issue-1.
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