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Objective: To determine the effect of 30% hyperoxia on the weight, fasting blood glucose (FBG) and serum peptide YY (PYY) levels in Sprague Dawley rats and to see its potential role in treating obesity. Study Design: Experimental, randomized control study. Place and Duration of Study: It was carried out at the Department of Physiology, Islamic International Medical College, Rawalpindi in collaboration with National Institute of Health, Islamabad, Pakistan from April 2015 to March 2016. Materials and Methods: Total 40 male Sprague Dawley rats of 2-4 months weighing 250-520 g were taken. They were divided into two groups of 20 each: control group A exposed to 21% oxygen and group B exposed to 30% oxygen for a period of 7 days. Before exposure to various oxygen concentrations the weight (g) of rats of both groups was taken and blood was collected for estimation of fasting blood glucose (FBG) (mg/dL) and serum peptide YY (PYY) (pg/mL).After exposure second sampling including weight, FBG and serum PYY was done. Statistical analysis was done applying SPSS 21, comparisons among the two groups were analyzed using independent sample t-test and correlation among variables was determined using Pearson's correlation coefficient. P value of <0.05 was considered significant in both analyses. Results: Group B rats had significantly (P<0.05) increased weight (g), increased FBG (mg/dL) levels (P<0.001) and low serum PYY (pg/mL) levels (P<0.001) in comparison with group A. Conclusion:Hyperoxia decreases PYY levels causing an increase in appetite leading to an increase in weight and FBG levels. Therefore, hyperoxia may not be useful as a treatment for obesity.

Muhammad Raza, Shazia Ali. (2017) Effect of Hyperoxia on Weight, Fasting Blood Glucose and Serum Peptide YY levels in Sprague Dawley Rats and its Potential Role in Treating Obesity, Journal of Islamic International Medical College, Volume-12, Issue-2.
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