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Objective: To determine the effect of Phloroglucinol Trimethylether vs Placebo on the duration of lu stage of
labour in term pregnancies.
Study Design: Quasi experimental study.
Place and Duration of Study: ObsJGynae wards IIMC, Railway hospital, Rawalpindi from June 2011 to May
2012.
Materials and Methods: A double blind randomized placebo controlled trial was conducted on 131 patients in
active phase of uncomplicated labour. The patients were randomized into two groups by simple random
technique. After evaluation, patients were divided into group A and B. Neither the patients northe doctor knew
about the injection of phloroglucinol or distilled water. Sixty five patients in group a received Phloroglucinol
Trimethylether 40 mg (4 ml) intravenous and 66 patients in group B received distilled water as placebo at 4 cm
cervical dilatation. Dose was repeated after 60 minutes. Maximum 3 doses were given. Progress of labour was
plotted on partogram_ Any adverse effects Of the drug on mother and fetus were noted. Studentt-testwas applied
forstatistical analysis.
Results: Out of 131 labouring patients, 61 patients from groupAand 61 patients from group B were included in
analysis, During 1" stageoflabour61 cases(100%) received 1 injection, whereas 1 1 cases (18.0%) were given 2
injectionsand 3 cases (4.91%) received 3 injections during the 10 stage oflabour ingroup Aand in group B 61
patients (100%) received 1 injection , 52 patients (852%) were given 2 injection and 37 cases (60.6%) were
received 3 injection. The average duration of observed active phase of 1 stage of labour was shortened by
almost two hours in patients receiving Phloroglucinol. The mean duration Of 2 "d stage Of labour in group A was
25.16mins and 34.52 mins in group B.
Conclusions: Phloroglucinol definitely has a therapeutic role to play in obstetrics With its strong antispasmodic
erect. In the presence Of good and regular uterine contractions, it shortens the duration Of labour, is non toxic to
both mother and fetus and it alsodecreases the severity of labour pain.
Raazia Rauf, Anser Begum, Umber Bakhtair, Asma Shaheen, Attiqa Ziagham, Azra Saeed. (2013) Phloroglucinol for Acceleration of Labour: Double Blind, Randomized Controlled Trial, Journal of Islamic International Medical College, Volume-8, Issue-1.
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