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Objective: To compare the complete healing of chronic anal fissure by using 2% nifedipine paste and 0.5%
glyceryl trinitrate ointment each applied locally for 6 weeks.
Study Design: Randomized Controlled Trail.
Place and Duration of Study: Surgical Unit-I, Pakistan Railway Hospital Rawalpindi spanning over a period of
06 months starting from March 2011 toAugust 2011.
Materials and Methods: Seventy six patients of chronic anal fissure were included in the study. Non-probability
convenience sampling was used for the enrolment of patients. Patients were divided equally into two treatment
groupsA& B. Group 'A' was treated with topical 2% nifedipine paste and Group 'B' was treated with 0.5% glyceryl
trinirate ointment. Patients were asked to come for the follow up after six weeks to look for symptomatic
improvement and healing rate.
Results: All 38 patients included in the study completed the follow up after 06 weeks of treatment in either group.
Three patients from Group B experienced intractable headache and were managed by analgesics accordingly
but they went on to complete the treatment. None of the patient in group A had any significant side effect causing
any adjustment in the treatment. At the end of 06 weeks of treatment, 28 patients in Group A and 25 in Group B
showed complete healing of anal fissure. The overall healing rate was 69.75 %( n=76). There was statistically no
significant difference at the end of 06 weeks of treatment (p=0.454).
Conclusion: It is concluded that 2% nifedipine paste is as effective as 0.5% GTN ointment in terms of healing of
chronic anal fissure.
Maliha Yunus, Mumtaz Akhtar, Zeeshan Ghani. (2013) Comparison of Topical Glyceryl Trinitrate and Nifedipine in Management of Chronic Anal Fissure, , Volume-8, Issue-1.
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