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OBJECTIVES: To determine the sensitivity of Immunohistochemistry for confirmation of diagnosis of prostate adenocarcinoma in our setup. METHODOLOGY: This descriptive cross sectional study was conducted at Pathology Department of Shaukat Khanum Memorial Cancer Hospital and Research Center, in a period of six months from September 2012 to March 2013, taking a sample size of 80 biopsy proven cases of prostatic Adenocarcinoma with Non-probability purposive sampling technique. SPSS version 16 was used for data analysis. The qualitative variables like expression of AMACR were presented as frequencies and percentages. Chi square was used with a p value <0.05 taken as significant. RESULTS: The mean ± SD age of patients was 67.81±7.25 years with a range from 51 to 85 years. The mean ± SD Gleason score of these patients was 6.99±1.52. About 51.2% (n=41) patients were of age group 61-70 years, 33.8% (n=27) were between 71-80 years, only 2.5% (n=2) were of age 81 years and above. Well-differentiated cases of prostatic adenocarcinoma were 3.8% (n=3), 52.5% (n=42) were moderately while 43.8% (n=35) were poorly differentiated. Out of all 100% (n=80) cases 91.2% (n=73) were expressed positive with AMACR staining while remaining 8.8% (n=7) were AMACR negative. CONCLUSION: AMACR staining is highly sensitive diagnostic tool and should be carried out in all patients who present with doubtful picture of prostatic cancer.
Suresh Kumar, Uzma Bukhari, Bushra Sikandar, Aneeta George, Yusra Memon, Nehad Khan, Asma Bukhari . (2020) Sensitivity of Alpha-Methylacyl-COA Racemase (AMACR) Staining in Prostatic Adenocarcinoma, Journal of Liaquat University of Medical and Health Sciences, Volume-19, Issue-4.
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