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BACKGROUND: Premenstrual syndrome (PMS) is a recurrent cyclic disorder of cyclical changes in the
sexual hormones. It is characterized by emotional, mental and physical symptoms, however
pathophysiology is largely unknown. Treatment with drugs like antidepressants, oral contraceptives,
GRH agonist has been tried. Recently it has been shown that the levels of 25-hydroxyvitamin D3 and
electrolytes such as magnesium have much importance in controlling the symptoms of PMS.
OBJECTIVE: To determine serum magnesium and 25-hydroxy cholecalciferol (25-OH-D3) in Premenstrual
syndrome (PMS) during luteal phase.
METHODOLOGY: This comparative study was conducted at the Department of Gynecology and
Obstetrics, Isra University Hospital during June-December 2013. Unmarried female (n=85) aged 18-28
years were selected through non-probability purposive sampling and divided into controls and those
having premenstrual syndrome (PMS). 25-hydroxy cholecalciferol (25-OH-D3) was estimated by
ARCHITECT I 1000 system and serum magnesium by DiaSys Merck system. Data was analyzed on SPSS
version 21.0. Significant p-value was taken at ≤ 0.05.
RESULTS: Vitamin 25-OH-D3 was found very low (14.88 ±SD2.39) in cases of PMS, as compared to
control (26.20 ±SD4.30) and difference was statistically significant (p=0.0001). Level of Vitamin 25-OH-D3
as low as 8 ng/dl was noted in PMS cases. Serum Mg++ was significantly differs between PMS cases and
controls 1.72 ±0.31 vs. 1.84 ±0.12 ng/dl (p=0.02). Vitamin 25-OH-D3 showed positive correlation with
serum Mg++ levels (r=0.24, p=0.02).
CONCLUSION: Serum magnesium and 25-hydroxychlecalciferol are low with positive correlation in
female having premenstrual syndrome.
Sadia Tabassum Abbasi , Palwasha Abbasi, Ahmed Hussain Suhag, Mumtaz Ali Qureshi. (2017) Serum Magnesium and 25-Hydroxy Cholecalciferol in Premenstrual Syndrome during Luteal Phase, Journal of Liaquat University of Medical and Health Sciences, Volume-16, Issue-4.
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