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OBJECTIVE: To determine the frequency of subgroups (germinal centre and non germinal centre) of Diffuse large B cell lymphoma (DLBCL) in a tertiary care hospital.
MATERIALS AND METHODS: It is a descriptive cross sectional study performed in histopathology department, clinical laboratories Dr. Ziauddin Hospital Karachi. 62 cases of Diffuse large B
cell lymphoma were collected during fifteen (15) months period from April 2011 to June 2012.
All resected specimens and small biopsies were grossed; sections were processed overnight
and stained by Hematoxylin and Eosin (H&E) for morphologic evaluation. The panel of lymphoid
antibodies included CD20, CD79a, CD3, Ki-67 & Pax5 were used for the diagnosis of DLBCL.
Then monoclonal antibodies CD 10, BCL-6 and MUM-1 were applied for subgrouping of DLBCL.
RESULTS: In a total of 62 cases of Diffuse large B cell lymphoma, 27 (44%) cases were categorized as germinal centre like subgroup and 35 (56%) were categorized as non germinal centre
like subgroup. Patient’s ages ranged from 04 to 95 years. 58% patients were males and 42%
were females with male to female ratio1.4:1. 36(58%) cases were extranodal and 26(42%) were
nodal lymphoma. Non germinal center like subgrpoup was preponderance in both nodal and
extranodal lymphoma as 15(58%) and 20(56%) respectively.
CONCLUSION: This study reports an increased number of patients of non germinal centre subgroup of Diffuse large B cell lymphoma. Male to female ratio was 1.4:1. Mean age of patient was
45 years.
Uzma Bukhari, Fouzia Lateef, Saba Jamal. (2015) Frequency of Subgroups of Diffuse Large B-Cell Lymphoma by Immunohistochemistry, Journal of Liaquat University of Medical and Health Sciences, Volume-14, Issue-2.
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