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OBJECTIVE: To observe the effect of single dose antibiotic is it as efficient as a 24-hour regimen in preventing SSIs in adults undergoing clean, clean contaminated and contaminated elective surgical procedures.
STUDY DESIGN: Random, prospective
SETTING AND DURATION: Department of general Surgery, Liaquat University Hospital, Jamshoro, Pakistan from May 2011 to April 2012
PATIENTS AND METHODS: A total of 208 patients undergoing general surgical operations were
included in the study. The patients were randomly divided into two groups. The single-dose
group received 2 grams of ceftriaxone intravenously, whereas the 24-hour group received 2
grams of ceftriaxone intravenously at the time of induction of anaesthesia, followed by 1 g at 8
and 16 hours postoperatively.
RESULTS: The administration of ceftriaxone in a single dose regimen was associated with
higher rate of SSIs compared with rates for patients receiving the 24-hour regimen (9.6% vs.
6.7%).
CONCLUSION: Multiple doses of prophylactic antibiotics over 24 hours should be used instead
of single doses in surgical prophylaxis in clean-contaminated and contaminated procedures.
Arshad H Abro, Ahmed Hussain Pathan, Faisal G Siddiqui, Faiza Syed, Abdul Aziz Laghari. (2014) Single Dose versus 24 - Hours Antibiotic Prophylaxis against Surgical Site Infections, Journal of Liaquat University of Medical and Health Sciences, Volume-13, Issue-1.
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