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OBJECTIVE: To determine the efficacy of Nepafenac 0.1% eye drops in maintaining mydriasis
during phacoemulsification cataract surgery.
METHODS: Patients of 40 – 65 years of age undergoing phacoemulsificaton cataract surgery
were randomly divided into two groups. One group received Nepafenac 0.1% eye drops and the
other group received placebo (Tears Naturale II eye drops).
Pre – operatively; all patients received tropicamide 1% eye drops and phenylephrine 2.5% eye
drops. The surgery in all the cases was done by the same ophthalmologist; with intra – operative epinephrine in the irrigating solution. The pupil size was measured with caliper at three
steps; immediately before the surgical incision (baseline), at the end of phacoemulsification,
and at the end of surgery.
RESULTS: 60 eyes of 60 patients were included in the study. 30 eyes were in the Nepafenac
0.1% group and another 30 in the placebo group. The mean age of our patients was 54.18 ± 7.49
years. The mean diameter of pupil at end of surgery was 7.65 ± 0.71 mm in Nepafenac group V/s
6.67 ± 0.97 mm in the placebo group (P– Value < 0.001).
In the Nepafenac group; the pupil size at the end of surgery decreased by a mean of 0.55 ± 0.51
mm (range 0.00 – 1.50 mm). Meanwhile; in placebo group the pupil size decreased by a mean of
1.05 ± 0.87 mm (range 0.00 – 3.5 mm). This difference was statistically significant (P = 0.009).
CONCLUSION: The pre – operative use of Nepafenac 0.1% eye drops was effective in maintaining mydriasis during phacoemulsification cataract surgery.
Sajjad Ali Surhio, Muhammad Memon, Rafeen Talpur, Khalid Iqbal Talpur. (2013) Efficacy of Nepafenac 0.1% in Maintaining Mydriasis during Phacoemulsification Surgery, Journal of Liaquat University of Medical and Health Sciences, Volume-12, Issue-2.
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