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OBJECT: To assess the role of Topiramate in reducing migraine related disability and improvement in quality of life in migraine sufferers comparing with conventionally used drug propranolol.
BACKGROUND: Epilepsy and migraine have some biological features in common; therefore antiepileptic drugs are suppose to be effective in migraine prophylaxis beside active treatment, in
reducing migraine headache attacks and therefore can improve sufferers’ quality of life.
METHODS: Seventy diagnosed patients of migraine were enrolled in the study and 64 completed the whole study period (12 weeks). They were divided in two groups: A (Topiramate) and
B (Propanolol). MIDAS scores were observed at day-0 and day-90 and results were statistically
analyzed.
RESULTS: Group received Topiramate showed better response and overall reduction was
62.51% (P-value<0.001) while in Propranolol group the reduction was 52.64% (p-value <0.001).
CONCLUSION: Topiramate is superior than olden propranolol in reducing the migraine related
disability and improving the daily activities related to job, school, household, family and social
life. However propranolol is still effective in migraine prophylaxis.
M.Jamil Laghari, Nasrin Qazi , Shanawaz Jamali , Ghulam Mustafa. (2012) Role of Topiramate in Improving Quality of Life in Migraine Sufferers versus Gold Standard Propranolol , Journal of Liaquat University of Medical and Health Sciences, Volume-11, Issue-1.
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