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Background: Peroxisome proliferator-activated receptors are the receptors that switch-on DNA responding
elements as heterodimers with nuclear retinoic acid. These are the transcription factors and belong to the
family of nuclear receptors and key regulators for lipid and glucose metabolism.
Methods: The study was designed to investigate the effect of edible oil on PPAR Alpha & Gamma expression
on rabbit liver.
Results: Reduced Glutathione (GSH) activity showed a significant increase and glutathione peroxidase (GPx)
activity showed a significant decrease in batch II and batch III in comparison to control group was observed. Out
of the total 3 batches, an increase was significantly increased in batch III (160%) in comparison to batch II
(151%). Inedible oil-treated Batches, PPAR α, and PPAR γ levels were found to decrease significantly for the
control batch. The decrease in PPAR alpha levels in batch II and batch III was 1.7 and 2.2 fold with p<0.01. In
the case of PPAR gamma, the corresponding values increased by 1.6 and 2.4 fold respectively with p<0.01.
Conclusion: The study demonstrated that edible oil supplementation significantly increases mRNA levels up to
two-fold in comparison to the control batch.
Syed Nasir Ahamed, Johra Khan, Syed Rahamathulla, T.C. Venkateswarulu, S. Krupanidhu. (2020-2021) Metabolic and molecular effects of edible oils on PPAR modulators in rabbit liver, Advancements in Life Sciences, Volume-8, Issue-2.
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