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Objective: The study was done to determine the association of serum CA-125 levels with the severity of endometriosis according to the Revised ASRM scoring system.
Methodology: It was cohort study of patients with diagnosed endometriosis undergoing laparoscopy, conducted at mother and child health center, PIMS hospital Islamabad between January 2017 to January 2018. A cohort of 100 patients was selected, using WHO sample size calculator for laparoscopy with diagnosed endometriosis. The technique used for sampling was convenience sampling considering the nature of the research. Serum CA-125 levels were determined preoperatively for all patients and levels were compared with the laparoscopically assigned stage of endometriosis according to the revised ASRM scoring system. All the selected patients had diagnosed endometriosis with ovarian involvement (endometrioma), while the preliminary diagnosis was made by a detailed gynaecological history, physical examination, transvaginal ultrasonography, MRI, and serum CA-125 levels. After doing the data collection procedure, for the data analysis, Pearson correlation was performed; MS Excel and SPSS 20.0 were used to analyze and interpret the results.
Results: The value of Pearson coefficient for the selected variables and the collected dataset indicated the large or high relationship between serum CA-125 levels and severity of endometriosis. Sig. (2-tailed) value i.e. 0.000 also indicated that the findings are highly significant.
Conclusion: Serum CA-125 is an indicator of the severity of endometriosis and it is important to consider it when surgical treatment is considered or necessary.
Sobia Luqman, Fatima Qazi, Shumaila Naeem, Nasira Tasnim. (2020) Association of CA-125 Levels with the Severity of Endometriosis, Journal of the Society of Obstetrics and Gynaecologists of Pakistan , Volume-10, Issue-4.
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