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Hepatitis B is a severe health issue in both developed and developing countries that infects approximately 3.5 billion individuals globally. HBV infection is a more contagious disease than HCV and HIV infection. The current research work was conducted at D.H.Q hospital, Mardan Khyber Pakhtoon Khwa (KPK). Only HBsAg positive patients (n=750) were selected and for further confirmation of HBV DNA in all patients, Real Time PCR was performed. Out of a total of 750 patients, 34.6 % (n=260) patients were found to be HBV positive using Real Time PCR method. Prevalence of HBV DNA was high in male patients (p= 0.0151) as compared to female patients and also in patients of older age (>60 years). All patients were divided into three groups on the basis of viral load, that is, low viral load 100-10000 IU/ml, intermediate viral load 100,000-10,000,000 IU/ml, and high viral load >10,000,000 IU/ml. The study showed that 61.15% patients were placed in intermediate viral load category. All the HBV DNA positive patients were also screened for HBeAg and 31.53% were found reactive for HBeAg. This study provides a clear spectrum of molecular epidemiology of HBV in the Mardan region of KPK, Pakistan.
Muhammad Waqar, Muhammad Arif Khan, Zobaria Rehman, Muhammad Idrees, Muhammad Wasim, Amina Asghar, Qazi Shah Rukh. (2019) Hepatitis B Virus (HBV) a Severe Health Problem in Mardan, Khyber Pakhtunkhwa, BioScientific Review, Volume 1, Issue 1.
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