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Thioacetamide (TAA) has been widely utilized in the development of animal models of hepatic damage by a number of researchers. The current investigation was designed to evaluate changes in tissue and serum total proteins and albumin along with urea, uric acid and serum transaminases activity after 12 and 24h of TAA administration in albino
rats. Rats were randomly divided into three groups (n=3) namely control group, 12h group and 24h group. Each experimental group (12h and 24h) was administered 300 mg/ kg TAA intraperitoneally (i.p) while control received same volume of normal saline solution. Rats of 12h and 24h group were killed after 12 and 24h of TAA administration
respectively. Blood was obtained; livers were excised and processed for protein profile and transaminases activity analysis. TAA injection resulted in significant alterations in serum proteins and transaminases levels. Significant hypoproteinemia and hypoalbuminemia were observed in sera as well as liver tissue of both experimental groups compared to control. Furthermore, transaminases activity was significantly increased for both; AST (P=0.0045) and ALT (P=0.0015) in both experimental groups when compared to control. Taking in account these results it can be concluded that TAA induces changes in the liver marker enzymes along with the change in the sera and tissue total protein contents specifically albumin.
Nadeem Sheikh, Muhammad Babar Khawar, Muddasir Hassan Abbasi, Khawaja Abdul Mujeeb, Sana Fatima. (2016) Alterations in proteins and transaminases activity induced by thioacetamide in albino rats, Punjab University Journal of Zoology, Volume 31, Issue 2.
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