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Solanum nigrum is used in local medicinal system to cure many metabolic disorders and oxidative stress-oriented health problems. Current work was performed to optimize the extraction process using freeze drying assisted ultrasonication for better antioxidant activities and lipoprotein lipase inhibitory properties. The 80% ethanolic extract exhibited considerable Fe-chelating activity (65.82 ± 1.26%), βcarotene bleaching inhibition (75.10 ± 0.90%) and lipoprotein lipase inhibitory properties (IC50 = 45.99 ± 2.12 µg/mL). The 20% ethanolic extract exhibited least antioxidant and enzyme inhibition activities. The variations in the activities of different extracts were probably due to solvent polarity set by the solvent components. The antioxidant and enzyme inhibition properties were most probably due to variety of phytochemicals present in extract. The Solanum nigrum was proved as a good source of natural antioxidants and anti-obesity agents which might be explored for novel pharmacological leads to treat obesity in safe and effective way.
ZAIN UL AABIDEEN, MUHAMMAD WASEEM MUMTAZ, MUHAMMAD TAYYAB AKHTAR. (2021) In vitro antioxidant and lipoprotein lipase inhibitory properties of freeze drying assisted ultrasonicated extracts of Solanum nigrum, Biologia – Journal of Biological Society of Pakistan, Volume 67(I), Issue 1.
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