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Estimation of C-reactive protein (CRP) is widely considered for investigating the degree of inflammation especially in coronary heart disease (CHD) and ischemic stroke (IS). A variety of studies have been conducted. However, precise correlation of age-related hs-CRP levels with the severity of injury is not known. Hence, we carried out present study in age-matched (age range 55-66 years) female patients of ischemic stroke (IS), epilepsy (E), post-ischemic stroke epilepsy (pIS-E) and ischemic heart disease (IHD) and compared with the normal female control subjects (C). Group comparisons showed significant variations of hs-CRP (mg/L) for IS vs. C, E vs. C, pIS-E vs. C, IHD vs. C, IHD vs. E, E vs. IS and IHD vs. pIS-E and non-significant change for pIS-E vs. IS, IHD vs. IS and pIS-E vs. E, that revealed the role inflammation via change in hs-CRP not only in patients with ischemic disorders but also in epilepsy patients though the extent of increase in hs-CRP was quite less in epilepsy patients. Moreover, significant positive correlation of age and hs-CRP levels was revealed for the mentioned female patients with ischemic disorders and epilepsy. Conclusively, we investigated the role and involvement of hs-CRP in female patients with ischemic stroke, ischemic heart disease and post-ischemic stroke epilepsy and also in patients with epilepsy without apparent involvement of ischemic complications. Hence, inflammation seems a major factor causing atherosclerotic conditions in neurovascular and cardiovascular disorders.
Samir Mohammed Abdulfattah Attia, Yaser Hasan Bahakeem, Abdulhalim S. Seraf, Zahir Hussain, Gisela H. Mai, M.H. Hussain, Mohammed A. Bafail. (2020) HIGH SENSITIVITY CRP IN FEMALE PATIENTS WITH ISCHEMIC STROKE, EPILEPSY, POST-STROKE EPILEPSY AND ISCHEMIC HEART DISEASE, , Volume 17, Issue 3.
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