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In order to investigate the frequency of common mitochondrial mutations in cervical cancer patients, the frequency of A1555G, A3243G and A7445G mutations in patients with cervical cancer in Lorestan province were studied. In this study, 50 women suffering from cervical cancer and 50 healthy women as control group were studied. Samples were screened by PCR-RFLP for common mtDNA mutations. The observed mutations were confirmed by sequencing. Frequency of alleles was analyzed using POPGENE Version 1.32 software and the results were analyzed using Prism 6 Graph Pad software. After analyzing the results, it was shown that there were no significant differences between the two groups for the A1555G, A7445G, and A3243G mutations. Regarding the relationship between the three mitochondrial genes with cervical cancer, it was found that there was no significant difference between the studied groups in the rate of studied mutations. The results of this study showed that there was no significant difference in the rate of mutations in the studied groups. In fact, according to the results of this study, mutation in A1555G, A7445G and A3243G cannot be considered as a diagnostic biomarker in cervical cancer.
Ayat Mohebifar, Kyumars Safinejad, Reihaneh Hoveida. (2020) IDENTIFICATION OF COMMON MITOCHONDRIAL MUTATIONS IN CERVICAL CANCER, , Volume 17, Issue 2.
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