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In the present study, effect of olive oil and its interaction with metformin, a well-known oral hypoglycemic agent was studied using alloxan induced diabetic model in rats. Animals were treated with olive oil at two different doses of 2 mL/kg or 4 mL/kg once daily through oral route and metformin was administered orally at a dose of 150 mg/kg. The serum glucose levels, serum insulin levels and lipid profile were estimated after four weeks of treatment. Olive oil showed antidiabetic effect as indicated by reduction in serum glucose levels and an increase in serum insulin levels. The effect on Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) was not evident except in animals treated with higher dose of olive oil (4 mL/kg, p.o) along with metformin (150 mg/kg, p.o). Olive oil also showed favorable effect on lipid profile in diabetic rats. It reduced total cholesterol, triglycerides, VLDL and LDL levels and its effect was potentiated by metformin. The results of the present study further confirm the beneficial properties of olive oil in diabetes and its favorable interaction with metformin, which could help in reducing dose of the later.
Monjid Ahmed Ibrahim Ahmed, Omar Fudal Idris, Mohammed Asad, Kamal Abdelsalam Ahmed, Ammar Mohammed Ali Mohammed, Abdul Rahman AI Alyahya. (2019) EFFECT OF OLIVE OIL ON INSULIN RELEASE, INSULIN RESISTANCE AND LIPID PROFILE AND ITS INTERACTION WITH METFORMIN IN ALLOXAN INDUCED DIABETIC RATS, , Volume 16, Issue 4.
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