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In present study different doses (0.3125, 0.625, 1.25 and 2.5µg of permethrin/0.1ml/egg) were evaluated for their strength of teratogenicity in developing chicks. The doses were prepared in corn oil and injected into eggs on 4th day of incubation. Following recovery on day 7, the embryos were analyzed morphologically and morphometrically. Morphological studies showed different abnormalities such as spina bifida, gastroschisis, exencephaly, hydrocephaly, micromelia, micrognathia, ectopia cordis, meningocephalocoel and microphthalmia. The morphometric analysis showed significant decrease in body weight and crown- rump length. These results suggest that even lower doses of permethrin are potentially toxic to developing chick.
Shagufta Andleeb, Shabana Kalsoom, Samra Ghazanfar, Shabana Shaukat, Saira Hanif. (2014) Developmental anomalies induced by permethrin in Gallus domesticus, , Volume 29, Issue 2.
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