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ti-emetic activity of ethanolic extract of Cymbopogon citratus leaves was investigated by anti-emetic assay at 300 and 500mg/kg
doses in young male chicks. Acute oral toxicity test was also performed to confirm the safety of the test drug. The results showed that
crude extract is safe up to the dose of 7.5g/kg body weight of animals. C. citratus extract at 500mg/kg dose possesses significant
activity just equal to the standard drug while at 300mg/kg dose the drug showed only mild activity. The results were compared with
that of standard and control groups. Domperidone in recommended dose i.e. 0.15mg/kg body weight was used as standard anti-emetic
drug, while control group was treated with distilled water. Phytochemical analysis was also carried out which showed the presence of
certain phytoconstituents in test drug that are responsible for anti-emetic activity.
Zahra Yaqeen1 , Naeem-ul-Hassan Naqvi2 , Nudrat Fatima1 , Hina Imran1 , Tehmina Sohail1 , Atiq-ur-Rahman1 , Zakir-ur-Rehman, and Shazia Syed3. (2011) EVALUATION OF ANTI-EMETIC ACTIVITY OF CYMBOPOGON CITRATUS (DC.) STAPF, , Volume 08, Issue 3.
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