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Hyperlipidaemia is one of the major contributors to atherosclerosis and coronary heart disease in our society. Non-pharmacological therapy especially dietary therapy and exercise are the first line of treatment in hyperlipidaemia, however pharmacotherapy is used in patients who are at high risk of coronary heart disease or patients who do not respond to non-pharmacological therapy. Present study is designed to investigate the effectiveness of fresh grated ginger (Zingiber officinale) administration over statin therapy. Age matched female rabbits were divided into three experimental groups. Base line values of all parameters were observed and animals were then administered atherogenic diet for four weeks. Lovastatin were fed @ 200mg/kg of body weight/ day ginger and 20mg/kg of body weight /day to these hypercholesterolemic rabbits for another four weeks. At the end of experimental period blood specimens were obtained and assayed for alterations in plasma lipid profile and glutamate pyruvate transaminase levels. Results of the present study were showed that both ginger and lovastatin reduce plasma cholesterol, LDL-C and triglyceride levels and increase plasma HDL-C levels, but significant results were obtained with lovastatin therapy. GPT levels were significantly reduced only with ginger administration. These findings suggests that dietary supplementation of ginger alone cannot be used effectively for secondary prevention trials, but for primary prevention trials due to adverse effects of Lovastatin on liver functions it can be used effectively.
Nazish Iqbal Khan, Ghazala Yasmeen, Ruqaiya Arshad. (2006) COMPARATIVE HYPOLIPIDEMIC EFFECTS OF GINGER (ZINGIBER OFFICINALE) AND LOVASTATIN IN CHOLESTEROL FED RABBITS, , Volume 3, Issue 2.
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