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Male albino rats were orally administrated with three dosages of ergotamine. The highest dose of ergotamine (0.4167 mg/ml), caused severe damage to the liver tissue. At 0.06 mg/ml, the liver showed minor changes and normal structural pattern was intact. At the highest dose, the changes were very severe and normal pattern of hepatocytes and architecture of the liver tissue totally DISAPPEARED. Minor changes on hematological parameters were observed, no bacteremia was detected and fecal samples were normal. In vitro studies, ergotamine slowly induces well-sustained vasoconstriction that can not be eliminated with drug washout. It appears that, ergotamine tends to produce a pattern of subjective effects that varies as a function of dose.
Nabeel M. Ghanem, Aly Khan, F. M. Bilqees. (2006) TOXIC EFFECTS OF ERGOTAMINE ON THE LIVER AND BLOOD OF ALBINO RATS, , Volume 3, Issue 2.
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