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Hypericum perforatum is a medicinal plant which has been known in traditional medicine as anti-inflammatory and healing agent. The total content of hypericins was determined 0.101% in Iranian H. perforatum. The anti-inflammatory and analgesic effects of H. perforatum extract, a native plant of Iran, were studied using carrageenan induced edema, formalin, hot plate and writhing tests. 3h after carrageenan injection, similar activity against carrageenan-induced rat paw edema was observed with H. perforatum extract (100 and 150 mg/kg) and indomethacin (4 mg/kg). In the formalin test, the extract (25-250 mg/kg, i.p.) caused graded inhibition of both phases of formalin-induced pain
M. Mahmoudi, K. Morteza-Semnani, M. Saeedi, A. Javanmardi. (2006) HYPERICINS CONTENT, ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF IRANIAN HYPERICUM PERFORA TUM, , Volume 3, Issue 1.
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