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Macrophage activation syndrome (MAS) is a potentially lethal complication of chronic rheumatological conditions like ankylosing spondylitis, rheumatoid arthritis, and adult-onset Still’s disease (AOSD).It is a multisystem inflammatory syndrome caused by immensecytokine release from activated lymphocytes and macrophages.We give an account of the incidence of a twenty years old Asian girl suffering from non-remitting fever and an evanescent rash for last ten weeks. Physical examination and laboratory work-up suggested high grade fever, pancytopenia, hyperferritinemia, hypertriglyceridemia, hypofibrinogenemia and impaired liver function. Bone marrow biopsy was also done. It showed active hemophagocytosis. She was diagnosed as a case of Macrophage Activation Syndrome associated with Adult Onset Still’s disease. She was treated with high dose steroids and cyclosporine and recovered completely
Madeeha Gulzar, , Ali Sabir, Muhammad Afzal Hamdani, , Asma Saadia. (2018) MACROPHAGE ACTIVATION SYNDROME ASSOCIATED WITH ADULT ONSET STILL’S DISEASE, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 30, Issue 2.
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