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According to Parkinson's Disease Foundation (PDF), more than 10 million people worldwide are suffering from Parkinson's disease.1 Parkinson's disease (PD) is a chronic and progressive movement disorder. It involves the malfunctioning and death of the neurons in substantia nigra of brain that is responsible for producing dopamine, an inhibitory neurotransmitter. Symptoms of this disease include tremors, bradykinesia, rigidity, postural instability etc.Communication between the gut and the brain is not one way. It’s a bidirectional communication system in which reciprocal signals can be transferred. An important direct pathway is the vagus nerve. Therefore, any pathology in the gut can lead to brain pathology and vice versa. For example,enteric inflammation can induce a number of affects that ultimately alter CNS function.2 This gateway can provide wide therapeutic opportunities for various incurable brain pathologies such as Parkinson disease.
Zohair Hussain Ali Lilani,, Rabbia Tazeem, , Sarah Batool, , Muhammad Hammad, , Namra Sharief. (2018) GUT-BRAIN AXIS HYPOTHESIS-AN INNOVATIVE WAY TO CURE PARKINSON IN PAKISTAN?, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 30, Issue 2.
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