مقالے کی معلومات
جلد
شمارہ
مقالے کی قسم
زبان
تلخیص
Background:Rheumatoid arthritisinflammatory joint disease which is chronic in nature. Since long various researches are carried out to find the remedy of this disease but still a lot of work needed to be done. Methods: This comparative study was performed from March to August 2013 at Postgraduate Medical Institute, Lahore.A total of thirty-two female Sprague-Dawley rats were randomly divided into four equal groups (n=8); group A was kept as healthy control, group Bwas kept as positive control, group C was treated with thymoquinone and group D was treated withmethotrexate. Arthritis developed within two weeks in group B, group C and group D after giving a single shot of pristane intradermally.Treatment was started on day 15. At day 30 (time of dissection) pawweightand histopathological sections of ankle joints of all the animals were taken.Results: The resultsshownsignificant rise inpaw weight and score of histopathological parametersin group B, group C and group D when compared withhealthy control rats. Thymoquinone and methotrexate treated groups shown reduction in paw weight and score ofhistopathological parameters when compared to positive control rats withp-value 0.001each. The difference between groups C and D was insignificant (p-value 0.062). Conclusion: Study results supported the anti-inflammatory and disease modifying activities of thymoquinone as it significantly reduces both paw weight and histological parameters of joint inflammation
Dr.Rizwan Faisal,, Nisar Ahmad, Yahya Saleem Fahad, Sadia Chiragh. (2018) ANTI-ARTHRITIC EFFECT OF THYMOQUINONE IN COMPARISON WITH METHOTREXATE ON PRISTANE INDUCED ARTHRITIS IN FEMALE SPRAGUE DAWLEY RATS, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 30, Issue 1.
-
Views
480 -
Downloads
38