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Background:Oestrogenhas a physiological rolethroughoutthebodyincludingoralcavity. The effects aremediated bybindingtotwo receptorsinnucleus alpha andbeta,which are ligand-activatedtranscriptionfactors.Thealpha receptorshaveaprognostic significance in cancer of breast while inAdenoid cystic carcinoma of salivary glands theresults are inconsistent. This study was conducted to determine the oestrogen receptor Alpha staining in adenoid cystic carcinoma of salivary gland.Methods:Paraffinblocks of thirty cases of adenoid cystic carcinoma of salivary gland were retrieved and evaluated through immunohistochemistry by anti-oestrogen antibody clone 1D5.The intensity and proportion of nuclear staining was scored using Allred scoring system.Results: From totalof thirty cases, 5casesexpressed as mild staining ofoestrogen receptors using Allred scoring system.Threecasesofcribriform and two cases from tubularpattern expressed positivity. In the case series selection of our study cohort there was no association seen in age, gender, site and histological type of tumour with the expression of oestrogen receptor. Conclusion: Role of oestrogen is well established in breast cancers, someof salivary glandadenoid cystic carcinoma alsoexpressthesereceptors and could be involved in thepathogenesis.Further studies are recommended to seek possible explanation of variable staining pattern observed in many other studies, and also to determine the possible therapeutic use of tamoxifen in such tumours
Hasan Mujtaba,, Muhammad Atique, Iffat Batool, Muhammad Farooq Umer. (2017) IMMUNOHISTOCHEMICAL EVALUATION OF OESTROGEN RECEPTORSIN ADENOID CYSTIC CARCINOMA OF SALIVARY GLAND, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 29, Issue 4.
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