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Background: Acute coronary syndrome remains a dominant cause of high morbidity and mortality despite advancements in treatment This study was conducted to examine the utility of point-of-care test of heart-type fatty-acid binding protein (h-FABP) and compare it withthe point-of-care test of cardiac troponin I (cTnI) in the first 06 hours of STEMI.Methods:This cross-sectional, comparative studywhich was conducted inRawalpindi institute of cardiology, Rawalpindi, Pakistan, from January to June 2015.Serum samples of 125 patients with the diagnosis of STEMI, presenting withchest pain of less than 6 hours’ duration, were analysed for quantitative and qualitative determination of h-FABP and cardiac troponinI (cTnI) using rapid immunochromatographic technique in the emergency department. Samples were taken at presentation and after 12 hours.Results: Out of 125 patients,112 were males and 13 were females with a mean age of 54.26±9.53 years. The average symptom-to-sample time was 3.19±1.44 hours (median 3 hours). Mean h-FABP levels weresignificantly higher than the mean cTnI levels (29.10±30.66 vs 0.94±2.02; p=0.000). Overall, H-FABP was more sensitive than cTnI (72% vs 26.4%). The sensitivity of cTnI within 0–2, 2–4, and 4–6 hours of symptom onset was calculated to be 0%, 17.7%, and 75.9%, whereas sensitivity of H-FABP was 35.3%, 79.03% and 100% respectively. There was not a single patient who was cTnI positive and H-FABP negative as compared to 57 patients who were FABP positive and cTnI negative.Conclusion:h-FABP is a promising cardiac biomarker for the early identification of myocardial ischemia and infarction. It could be a superiorbiomarker for earlier detectionof ACS and screeningof patients with non-cardiac chest pain
Dr. Muhammad Saleem,, Muhammad Saleem,, Shahid Rasheed, , Azhar Mahmood Kiyani. (2017) UTILITY OF HEART TYPE FATTY ACID BINDING PROTEIN (H-FABP) POINT OF CARE TEST IN THE EARLY HOURS OF STEMI COMPARED WITH TROPONIN-I IN PAKISTANI POPULATION, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 29, Issue 1.
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