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Background:Non-infectious causes of chronic diarrhoea are important and easily missed.The study was done with the objectives to identify different causes of chronic non-infectious diarrhoeain infantsless than 6 months of age.Methods:All patients less than 6 months of agepresenting for the first time to aPaediatric Gastroenterology tertiary care centrewith a history ofchronic diarrhoea and negative stool cultures were enrolled over a period of 8 months. Demographical profile and various factors under observation were recorded in this observational study.Collected data wasanalysed using SPSS version 20.Chi square test was applied as a test of significance for any qualitative variable,p value (p<0.05) was taken as significant.Results:Among 72 enrolledpatients, female to male ratio was1.05:1. Age at onset of symptoms was between15 days to 6 months. Aetiologyfoundwas Cow’s milk protein allergy(CMPA) in 58(80.6%), Primary intestinal lymphangiectasia(PIL) 6(8.3%),Cystic fibrosis (CF) 3(4.2%), Immunodeficiency(SCID) 2(2.8%), 1(1.4%) for each Abetalipoproteinemia(ABL),Glucose galactose malabsorption(GGM) and Congenital chloride diarrhoea(CCD).Conclusions:Among non-infectious causes of chronic diarrhoeain early infancy, cow’s milk protein allergy is most common followed by Primary intestinal lymphangiectasia and Cystic fibrosis.Keywords: Chronic Diarrhoea;Cow’s Milk Protein Allergy; Primary Intestinal Lymphangiectasia; Cystic Fibrosis;Immunodeficiency;Abetalipoproteinemia;Glucose Galactose Malabsorption; Congenital Chloride Diarrhoea
Dr. Iqra Mushtaq,, Huma Arshad Cheema,, Hassan Suleman Malik, , Nadia Waheed,, Muhammad Almas Hashmi. (2017) CAUSES OF CHRONIC NON-INFECTIOUS DIARRHOEA IN INFANTS LESS THAN 6 MONTHS OF AGE: RARELY RECOGNIZED ENTITIES, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 29, Issue 1.
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