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A 51-year-old male presented to the Department of Oral and Maxillofacial Pathology, NIMS Dental College Jaipur (India) with a painless pigmented patch extending from left side of the palate to the gingiva from 9 months. The patient had noticed the growth 7 months ago; it was a small patch of 1 cm initially, which gradually increased to attain the present size. The lesion was completely asymptomatic without any ulceration and mobility of the teeth. The past medical history and family history were non – contributory. Bilateral sub – mandibular lymph nodes were palpable. Intra – oral examination revealed a brow n to black pigmented lesion of 3×2 cm in size; extending from left side of palate to attached, interdental and marginal gingival of left maxilla. The lesion extending from right maxillary lateral incisor to left maxillary second molar. With irregular and blurred borders(Figure-1). Based on clinical features a provisional diagnosis of malignant melanoma was considered with differential diagnoses of intra – oral nevus, haemangioma, vascular malformations and Kaposi’s sarcoma were considered. An incisional biopsy was performed under local anaesthesia and excised tissue was sent for histopathological examination.Haematoxylin and Eosin stained soft tissue section revealed infiltration of numerous atypical pleomorphic melanocytes in the connective tissue stroma. (Figure-2) Melanocytes contained brown – black pigments in cytoplasm. (Figure-3). With the correlation of all the clinical and histopathological features a final diagnosis of Malignant melanoma was rendered. Pigmented lesions are commonly found in the mouth. Such lesions represent a variety of clinical entities, ranging from physiologic changes to manifestation of systemic illness and malignant neoplasm. Diagnosis of such lesions requires a proper case history, extraoral and intraoral examination, and, in some cases, biopsy, aspiration cytology, and laboratory investigations
Dr. Manas Bajpai,. (2017) MALIGNANT MELANOMA OF ORAL CAVITY, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 29, Issue 1.
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